A few participants told us of a peculiar breakdown in the normal fluidity
of their vision: “Your movements were not your own, they were no
longer smooth and coordinated,” and “You guys looked robotic; moving
jerkier, more mechanical, geometric.”
About half the volunteers experienced auditory effects: sounds were different, or they heard things that we did not. These were most pronounced during the DMT rush. Sometimes this was little more than intensification of normal hearing. Others became functionally deaf and did not hear the grinding motor of the blood pressure machine or any other outside sounds.
However, it was quite rare for volunteers to hear formed voices or music. Rather, there were simply sounds, variously described as “highpitched,” “whining and whirring,” “chattering,” “crinkling and crunching.” Many remarked on the similarity of DMT auditory effects to those of nitrous oxide, where there is a “wah-wah,” oscillating, wavering distortion of sounds. Occasionally there were the sorts of things one hears in cartoons: comical “sproing, boing” noises.
Taken from : DMT The Spirit Molecule - Rick Strassman MD.
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There were more formed, specific visual images, too. These included “a fantastic bird,” “a tree of life and knowledge,” and “a ballroom with crystal chandeliers.” There were “tunnels,” “stairways,” “ducts,” and “a spinning golden disc.” Others saw the “inner workings” of machines or bodies: “inside a computer’s boards,” “DNA double helices,” and “the pulsating diaphragm around my heart.”
Even more impressive was the apprehension of human and “alien” figures that seemed to be aware of and interacting with the volunteers. Non-human entities might be recognizable: “spiders,” “mantises,” “reptiles,” and “something like a saguaro cactus.”
Visual effects lingered as volunteers’ bodies rapidly metabolized the DMT. The room was uncomfortably bright when they removed the eyeshades or opened their eyes. Objects in the room took on a wavy, undulating motion, radiating with their own inner light. Subjects commented on an exaggerated depth perception, sometimes being mesmerized by the patterns in the wooden bathroom door.
Taken from : DMT The Spirit Molecule - Rick Strassman MD.
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Visual images were the predominant sensory effects of a full dose of DMT. Usually there was little difference between what volunteers “saw” with their eyes opened or closed. However, opening the eyes often caused the visions to overlay what was in the room.
This had a disorienting effect, and it was less confusing to keep their eyes closed. That’s one of the reasons we decided to place black silk eyeshades on all the volunteers before we gave any DMT.
Subjects saw all sorts of imaginable and unimaginable things. The least complex were kaleidoscopic geometric patterns, which sometimes partook of “Mayan,” “Islamic,” or “Aztec” qualities. For example, “beautiful, colorful pink cobwebs; an elongation of light,” “tremendously intricate tiny geometric colors, like being one inch from a color television.”
The colors of this imagery were brighter, more intense, and deeper than those of normal awareness or dreams: “It was like the blue of a desert sky, but on another planet. The colors were a hundred times deeper.” Background and foreground distinctions might merge so that countless images would occupy a volunteer’s visual field. It was impossible to tell what was “in front” and what was “behind.” Many used the term “fourdimensional” or “beyond dimensionality” to describe this effect.
Taken from : DMT The Spirit Molecule - Rick Strassman MD.
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This tidal wave of DMT effects quickly led to losing awareness of the body, causing some volunteers to think they had died. This dissociation of body and mind paralleled the development of peak visual effects. We typically heard phrases like: “I no longer had a body,” “My body dissolved— I was pure awareness.”
There seemed to be a clearly identifiable sense of movement of consciousness away from the body, such as “falling,” “lifting up,” “flying,” a feeling of weightlessness, or rapid movement. Some male volunteers, but no females, experienced localized sensations in their genitals. While sometimes these were pleasurable, for others they were emotionally neutral or bland. No one ejaculated.
The rush of early effects almost inevitably caused some fear and anxiety. However, most volunteers quickly settled in to the experience within 15 to 30 seconds by deep breathing, physical relaxation, or whatever else they knew would help them to deeply let go. Perhaps because of their previous psychedelic experience, they frequently could separate their emotions from their body’s physical reaction without panicking.
Taken from : DMT The Spirit Molecule - Rick Strassman MD.
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It is difficult to do justice in describing the rush. My dictionary uses such terms as “a sudden turbulent movement, drive, or onset; a feeling of urgency or haste; a swift or violent movement.” Almost without thinking, several volunteers blurted out, as effects began, “Here we go!” Some comparedthis feeling to a “freight train,” “ground zero,” or a “nuclear cannon.”
Several people reported that the “breath caught in my throat” or “the wind was knocked out of me.” Those who previously had smoked DMT were at an advantage in being able to anticipate its disorienting onset. However, they believed the rush of IV DMT was more rapid and powerfulthan that of the smoked method.
Nearly everyone remarked on the “vibrations” brought on by DMT, the sense of powerful energy pulsing through them at a very rapid and high frequency. Typical comments were: “I was worried that the vibration would blow my head up,” “The colors and vibration were so intense Ithought I would pop,” “I didn’t think I would stay in my skin.”
Taken from : DMT The Spirit Molecule - Rick Strassman MD.
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It may be that outside-administered DMT was not a powerful-enough stimulus to overcome the pineal defense mechanism we’ve discussed previously. While it’s clear that stress hormones rose in response to the spirit molecule, they may not have gotten high enough to stimulate daytime melatonin production.
Another possibility is that exogenous DMT actually did stimulate the pineal to make more of its own endogenous DMT. However, our method of measuring DMT in the blood would not have been able to distinguishbetween the two sources of the spirit molecule.
Volunteers, of course, did not feel the rise in prolactin or experience in their consciousness their elevated blood pressure. Rather, it was in their minds that the images, feelings, and thoughts defined the essence of thespirit molecule’s effects.
The initial moments of the first non-blind high dose of DMT overwhelmed almost everyone. There was an intense, rapidly developing, and at least temporarily anxiety -provoking “rush” throughout the body and mind. This rush began even before I had finished the saline flush.
Taken from : DMT The Spirit Molecule - Rick Strassman MD.
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On average, heart rate, or pulse, bolted from about 70 beats per minute up to 100. The range, however, was wide. Some subjects’ pulse climbed up to 150, while others’ got no higher than 95. Blood pressure also jumped from values of about 110/70 to an average of 145/100. Heart rate and blood pressure fell as rapidly as they rose, already beginning to taper offbetween the 2- and 5-minute recordings.
Every pituitary gland hormone we measured increased rapidly. For example, blood levels of the endogenous morphine-like chemical betaendorphin begin a steep ascent at 2 minutes following DMT administration and reached their peak at 5 minutes. DMT also stimulated sharp spikes in the release of vasopressin, prolactin, growth hormone, and corticotropin.
The last is a hormone responsible for stimulating the adrenal glands, which then release cortisol, a powerful, all-purpose stress steroid similar to cortisone. The elevations of these hormones may have exerted somepsychological effects—I’ll discuss this in chapter 21.
Pupil diameter doubled, from 4 millimeters to nearly 8, with a high dose of DMT, with biggest responses at 2 minutes. Body temperature took longer to rise, beginning at 15 minutes and continuing to climb by the time we removed the rectal temperature monitor at 60 minutes. Of all the biological factors we measured, the only one that did not increase was the pineal gland hormone melatonin. This was startling, and again brought home to me the incredibly mysterious nature of this potentialspirit gland.
Taken from : DMT The Spirit Molecule - Rick Strassman MD.
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We measured levels of DMT in the blood frequently after injecting it and verified that the time course of psychological effects and DMT blood levels overlapped exactly. That is, blood levels of DMT reached their peak at 2 minutes and were nearly undetectable at 30. Since the brain actively transports DMT across the blood-brain barrier into its confines, it’s reasonablycertain brain levels of DMT rose as quickly as blood levels.
Lower doses of DMT, 0.1 and 0.05 mg/kg, generally were not psychedelic, but certainly produced some psychological effects. These were primarily emotional and physical, although some particularly sensitive people had significant psychedelic and physical responses to even these low doses. In fact, some volunteers dropped out because they didn’t like the intensity of 0.05 mg/kg. We also excused other subjects after this small dose because their blood pressure response made us worry about how their hearts would hold up after eight times that amount the next day.
While the profound psychological effects of DMT were progressing, the physical self followed suit with its own constellation of responses. The body initially reacted to a high dose of DMT with a typical “fight-or-flight” stress reaction. Heart rate and blood pressure jumped radically, their time course closely following the psychological responses. After a while we could almost predict how intense a volunteer’s session was by the rise intheir blood pressure.
Taken from : DMT The Spirit Molecule - Rick Strassman MD.
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